Recombinant tissue plasminogen activator (r-TPA) in fibrin dissolution due to postoperative endophthalmitis.

INTRODUCTION The aim of this paper was to describe the use of r-TPA for fibrin clot dissolution following endophthalmitis. CLINICAL PICTURE A 74-year-old man presented with painful loss of vision following routine uncomplicated cataract surgery. TREATMENT He underwent standard treatment for postoperative endophthalmitis but despite this, developed a dense fibrin clot. He underwent further intracameral injection of r-TPA. OUTCOME Following the injection, he had complete clot dissolution within 2 hours without any complications. CONCLUSION R-TPA may be used effectively in the treatment of fibrin clots secondary to endophthalmitis following cataract surgery.